Functional compensation by transplantation of cell suspensions of embryonic mesencephalon into the striatum of rats with 6-hydroxydopamine lesions.

نویسندگان

  • H Watanabe
  • Y Hiyama
  • H Suda
  • S Sekihara
  • K Terasawa
چکیده

Neuronal cell suspensions were implanted into the striatum of female rats that showed apomorphine-induced rotation and a reduction in striatal dopamine after intranigral treatment with 6-hydroxydopamine. The apomorphine-induced rotation was significantly suppressed by the transplantation in 12 out of 64 rats. DOPA accumulation and dopamine level (6.3 and 3.4%, respectively, compared with those of uncompensated rats) in the striatum following treatment with an amino acid decarboxylase inhibitor were slightly restored in compensated rats.

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عنوان ژورنال:
  • Japanese journal of pharmacology

دوره 40 4  شماره 

صفحات  -

تاریخ انتشار 1986